Journal article

Maternal Alcohol Intake and Offspring Pulse Wave Velocity

Ruth Morley, Terence Dwyer, Kristen L Hynes, Jennifer Cochrane, Anne-Louise Ponsonby, Helena C Parkington, John B Carlin

NEONATOLOGY | KARGER | Published : 2010

Abstract

BACKGROUND: Intrauterine exposure to alcohol may affect cardiovascular development, increasing risk of cardiovascular malformations. Intrauterine exposure to light maternal alcohol intake has been reported to affect human umbilical arterial contractility, and adult sheep exposed in utero have had altered cerebrovascular reactivity. In human adults, alcohol intake affects arterial stiffness. OBJECTIVES: We investigated whether intrauterine exposure to alcohol was associated with childhood pulse wave velocity (PWV), a measure of arterial stiffness. METHODS: On postnatal day 4, mothers of 147 twin pairs born in Tasmania from 1991 to 1993 reported alcohol intake during each trimester of pregnanc..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

This study was funded by the National Heart Foundation of Australia, and Ruth Morley is supported by a Senior Research Fellowship (350250) from the National Health and Medical Research Council of Australia (NHMRC).The Tasmanian Infant Health Study was funded by the NHMRC, US National Institutes of Health, Tasmanian State Government, Australian Rotary Health Research Fund, Sudden Infant Death Research Foundation, National Sudden Infant Death Syndrome Council of Australia, Community Organisations' Support Program of the Department of Human Services and Health, Zonta International, Wyeth Pharmaceuticals and Tasmanian Sanatoria After-Care Association.