Probes of behaviour regulation: Olfactory models in addiction

Abstract

The utility of olfactory probes for understanding disorders involving orbitofrontal compromise has been outlined in Chapter 6. In this chapter, we discuss how such investigations may also be applied to addiction, where current neurobiological models implicate dysfunction within the orbitofrontal cortex (OFC) as a core underlying feature (Lubman et al., 2004). Hence, the focus of the chapter is not on olfaction per se, but more broadly upon compromise of OFC structure and function. The aim is to model one example of how olfactory testing could be applied to investigations of OFC function and related behavioural outcomes. Specifically, we discuss how abnormalities within the OFC and associated..