A novel population of human CD56 human leucocyte antigen D-related (HLA-DR ) colonic lamina propria cells is associated with inflammation in ulcerative colitis: ORIGINAL ARTICLE

Abstract

Summary Ulcerative colitis (UC) involves inappropriate mucosal immune responses to intestinal microbiota. Gut dendritic cells (DC) are central immunoregulators of the response to commensal bacteria, and the subset of CD11c+ cells within the human leucocyte antigen D-related (HLA-DR+) lineage (lin)-/dim population are activated in inflammatory bowel disease. We hypothesized that CD11c- cells within this population may also be involved in intestinal inflammation. HLA-DR + lin-/dim cells were identified in freshly isolated lamina propria mononuclear cells by multi-colour flow cytometry in 54 UC patients and 22 controls. Proportion and number of CD11c+ and CD11c- cells, and surface expression of..