Journal article
Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: A review of the clinical evidence
M Garefalakis, M Hickey
Clinical Interventions in Aging | Published : 2008
DOI: 10.2147/cia.s1043
Abstract
Estrogen-containing hormone therapy (HT) is the most widely prescribed and well-established treatment for menopausal symptoms. High quality evidence confirms that estrogen effectively treats hot flushes, night sweats and vaginal dryness. Progestins are combined with estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot flushes, but are less effective than estrogen for this purpose. Data are conflicting regarding the role of androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot flushes and vaginal dryness. Tibolone may improve libido more effectively than estrogen containing ..
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Funding Acknowledgements
Dr Maria Garefalakis has undertaken clinical research sponsored by Organon, Pfizer, GlaxoSmithKline and Schering AG and has been sponsored by these companies to attend international meetings. She has received an honorarium for speaking at a symposium sponsored by Astrazeneca.Dr Martha Hickey has been reimbursed for attending symposia by Wyeth, Organon, and Novo Nordisk; has also received honoraria for speaking at symposia sponsored by pharmaceutical companies for national and international meetings from Novo Nordisk, Wyeth, Schering and Organon; and is undertaking clinical research sponsored by Organon, Pfizer and Schering AG. She has received unrestricted educational grants from Astra Zeneca and Organon