Journal article

Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

R Hodges, L Salvador, D D'Antona, HM Georgiou, EM Wallace

JOURNAL OF PERINATOLOGY | NATURE PUBLISHING GROUP | Published : 2010

Abstract

OBJECTIVE: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM). STUDY DESIGN: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks' gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review. RESULT: Eighteen women with PPROM were studied, with seven developing intrauterine infectio..

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