Journal article

Global comparative transcriptome analysis of cartilage formation in vivo

Trevor L Cameron, Daniele Belluoccio, Peter G Farlie, Bent Brachvogel, John F Bateman



BACKGROUND: During vertebrate embryogenesis the initial stages of bone formation by endochondral ossification involve the aggregation and proliferation of mesenchymal cells into condensations. Continued growth of the condensations and differentiation of the mesenchymal cells into chondrocytes results in the formation of cartilage templates, or anlagen, which prefigure the shape of the future bones. The chondrocytes in the anlagen further differentiate by undergoing a complex sequence of maturation and hypertrophy, and are eventually replaced by mineralized bone. Regulation of the onset of chondrogenesis is incompletely understood, and would be informed by comprehensive analyses of in vivo ge..

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Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia and the Murdoch Childrens Research Institute. The authors thank the Murdoch Childrens Research Institute Bioinformatics Unit, for assistance with gene ontology analysis.