Journal article
Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response
C Lee, TB Kolesnik, I Caminschi, A Chakravorty, W Carter, WS Alexander, J Jones, GP Anderson, SE Nicholson
Clinical and Experimental Allergy | WILEY | Published : 2009
Abstract
Background The molecular determinants of the severity and persistence of allergic asthma remain poorly understood. Suppressor of cytokine signalling 1 (SOCS1) is a negative regulator of IL-4-dependent pathways in vitro and might therefore control T-helper type 2 (Th2) immunity associated traits, such as IgE levels, mucin production, IL-5 and IL-13 induction, and eosinophilic mucosal inflammation, which are implicated in allergic asthma. Objective To investigate the role of SOCS1 in regulating Th2-associated disease traits in a murine sub-chronic aeroallergen-driven asthma model. Methods Following sensitization and challenge with ovalbumin (OVA), bronchoalveolar lavage and serum were collecte..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported in part by the National Health and Medical Research Council (NHMRC), Australia (Programme grant #461219, Project grant #461232) and in part by the National Institutes of Health (RO1 CA22556-26). C. L. was supported by an Alan Harris Student Scholarship, S. E. N. by an NHMRC Biomedical Career Development Award and Fellowship (#516705) and W. S. A. by an NHMRC Fellowship (#305503). We are grateful to D. Metcalf for instruction in differential cell counts, and T. Kay and R. Starr for provision of Socs1<SUP>Lck-Cre</SUP> blood samples. We thank Michele Grimbaldeston (IMVS, SA) for the kind gift of OVA-specific IgE antibodies. We thank G. Siciliano and J. McSween for excellent animal husbandry.