Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
M Eikermann, S Zaremba, A Malhotra, AS Jordan, C Rosow, NL Chamberlin
BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2008
BACKGROUND: Cholinesterase inhibitor-based reversal agents, given in the absence of neuromuscular block, evoke a partial upper airway obstruction by decreasing skeletal upper airway muscle function. Sugammadex reverses neuromuscular block by encapsulating rocuronium. However, its effects on upper airway integrity and breathing are unknown. METHODS: Fifty-one adult male rats were anaesthetized with isoflurane, tracheostomized, and a femoral artery and vein were cannulated. First, we compared the efficacy of sugammadex 15 mg kg(-1) and neostigmine 0.06 mg kg(-1) to reverse respiratory effects of rocuronium-induced partial paralysis [train-of-four ratio (T4/T1)=0.5]. Subsequently, we compared t..View full abstract
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This work was supported by a grant from Organon International Inc., a part of Schering-Plough Corporation. Organon did not participate in generation of the protocol, data analysis and interpretation, or writing.