Journal article
Imaging Cellular Proliferation During Chemo-Radiotherapy: A Pilot Study of Serial 18F-FLT Positron Emission Tomography/Computed Tomography Imaging for Non-Small-Cell Lung Cancer
S Everitt, RJ Hicks, D Ball, T Kron, M Schneider-Kolsky, T Walter, D Binns, M Mac Manus
International Journal of Radiation Oncology Biology Physics | Published : 2009
Abstract
Purpose: To establish whether 18F-3′-deoxy-3′-fluoro-l-thymidine (18F-FLT) can monitor changes in cellular proliferation of non-small-cell lung cancer (NSCLC) during radical chemo-radiotherapy (chemo-RT). Methods and Materials: As part of a prospective pilot study, 5 patients with locally advanced NSCLC underwent serial 18F-FLT positron emission tomography (PET)/computed tomography (CT) scans during treatment. Baseline 18F-FLT PET/CT scans were compared with routine staging 18F-FDG PET/CT scans. Two on-treatment 18F-FLT scans were performed for each patient on Days 2, 8, 15 or 29, providing a range of time points for response assessment. Results: In all 5 patients, baseline lesional uptake o..
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Funding Acknowledgements
This work was supported by an Australian Institute of Radiography research scholarship (SJE). The authors wish to thank Michael Sproston and Anne Louev for their significant role in positioning patients for the PET/CT scans and Colin Homby for his technical assistance in data transfer. Thank you also to Associate Professor Grant MacArthur for his editorial review of the manuscript.