Journal article
Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine
T Nolan, TA Ruff, SB Lambert, J Buttery, KA O'Grady, C Streeton, B Hoet, HL Bock
Vaccine | ELSEVIER SCI LTD | Published : 2009
Abstract
Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18-20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and ≥93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016 IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who d..
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Funding Acknowledgements
This study was funded by GlaxoSmithKline Biologicals, Melbourne, Australia. The contributions of the following research staff are gratefullyacknowledged: Janet Briggs, Dale Cooper, Susie Gabriel, Genevieve Hamilton, Tara Harris, Marita Kefford, Jacinta O'Sullivan, Deb Saunders, Barb Sherry, Amanda Tehan, and Helen Worland. We also thank maternal and child health nurses for their assistance in recruitment and parents for allowing us to enrol their children. The authors thank Dr. Joanne Wolter, Avishek Pal and Roselynn Tien for assistance in preparation of the manuscript and Gunasekaran Ramakrishnan for providing statistical input.