Journal article
Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area
KJM Brolin, KEM Persson, M Wahlgren, SJ Rogerson, Q Chen
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Background: Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity. Methods: Using VAR2CSA DBL-domains expressed on the surface of CHO-745 cells we quantified levels of DBL-doma..
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Awarded by National Institutes of Health
Funding Acknowledgements
Q.C. is supported by grants from the National Basic Research Program of China (973 Program, No. 2007CB513100), SIDA/SAREC (www.sida.se) and the EU malaria network of excellence (BioMalPar) program (www.biomalpar.org). S.J.R. is supported by the National Health and Medical Research Council of Australia (www.nhmrc.gov.au). K.J.M.B. was supported in part by a travel grant from Boehringer Ingelheim Fonds (www.bifonds.de) and by Kvinnor Kan (www.kvinnorkan.se). K. E. M. P. is supported by The Wenner-Gren Foundations (www.wennergren.org), Vinnova (www.vinnova.se), O E and Edla Johanssons Foundation (www.oejvetstift.se) and Jeanssons Foundation (www.jeanssonsstiftelser.se). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.