Journal article
Investigation of reproductive toxicity of piperaquine in mice
KT Batty, BR Moore, V Stirling, KF Ilett, M Page-Sharp, KB Shilkin, I Mueller, SJ Rogerson, HA Karunajeewa, TME Davis
Reproductive Toxicology | Published : 2010
Abstract
Reproductive toxicity data for the antimalarial drug piperaquine (PQ) were obtained in pregnant mice (F0) and their offspring (F1 and F2). PQ phosphate (0-300mg/kg/day) was given to pregnant Swiss mice from gestational days 14-18. Two F1 pups from each litter (one male and one female) proceeded to maturity and were mated within dose groups. Biochemical and haematological indices were determined, and liver and kidney histopathology was assessed in F1 and F2 mice at 4 weeks. There were no significant dose-related adverse effects, but leucocytes were mildly elevated (F1 and F2 mice) and serum albumin was reduced (F1 only) in the 300mg/kg/day group. Low plasma PQ concentrations were detected in ..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The authors thank Dr Paul Chubb, PathWest Laboratory Medicine WA, Fremantle Hospital and Health Service, for the biochemical tests and Dr Richard Parsons, Curtin University, for statistical advice. The present study was supported by a Project Grant (458555) from the National Health and Medical Research Council of Australia. TMED is supported by a National Health and Medical Research Council of Australia Practitioner Fellowship.