Journal article
Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
AC Hurt, JK Holien, M Parker, A Kelso, IG Barr
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2009
DOI: 10.1128/JVI.01200-09
Abstract
The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viruses in Europe, the United States, Oceania, and South Africa, to date there have been no reports of significant zanamivir resistance among influenza A (H1N1) viruses or any other human influenza viruses. We investigated the frequency of oseltamivir and zanamivir resistance in circulating seasonal influenza A (H1N1) viruses in Australasia and Southeast Asia. Analysis of 391 influe..
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Funding Acknowledgements
We thank the Research Institute for Tropical Medicine (Manila, Philippines), Queensland Health Services (Brisbane, Australia), Canterbury Health Services (Christchurch, New Zealand), and the WHO National Influenza Centre, National Institute of Health (Bangkok, Thailand), for submitting the viruses investigated in this study. In addition we thank all of the other laboratories that have submitted samples used in this study to the WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia. We also thank Naomi Komadina, Yi-Mo Deng, and Pina Iannello for undertaking the sequence analysis of some isolates and Robert Shaw, Chris Durrant, and Helen Sjogren for the culture of isolates used in the surveillance study.The WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.