The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders
Jess Nithianantharajah, Anthony J Hannan
PROGRESS IN NEUROBIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009
The concept of 'cognitive reserve', and a broader theory of 'brain reserve', were originally proposed to help explain epidemiological data indicating that individuals who engaged in higher levels of mental and physical activity via education, occupation and recreation, were at lower risk of developing Alzheimer's disease and other forms of dementia. Subsequently, behavioral, cellular and molecular studies in animals (predominantly mice and rats) have revealed dramatic effects of environmental enrichment, which involves enhanced levels of sensory, cognitive and motor stimulation via housing in novel, complex environments. Furthermore, increasing levels of voluntary physical exercise, via ad l..View full abstract
AJH is supported by project grants from the NHMRC and a Pfizer Australia Research Fellowship.