Journal article

Bypassing luminal barriers, delivery to a gut addressin by parenteral targeting elicits local IgA responses

BS McKenzie, AJ Corbett, S Johnson, JL Brady, J Pleasance, DR Kramer, JS Boyle, DC Jackson, RA Strugnell, AM Lew

INTERNATIONAL IMMUNOLOGY | OXFORD UNIV PRESS | Published : 2004

Abstract

Induction of mucosal immunity, particularly to subunit vaccines, has been problematic. The primary hurdle to successful mucosal vaccination is the effective delivery of vaccine antigen to the mucosal associated lymphoid tissue. Physical and chemical barriers restrict antigen access and, moreover, immune responses induced in the mucosa can be biased towards tolerance or non-reactivity. We proposed that these difficulties could be circumvented by targeting antigen to the gastrointestinal associated lymphoid tissue via systemic (parenteral) rather than alimentary routes, using antibodies specific for the mucosal addressin cellular adhesion molecule-1 (MAdCAM). After intravenous or intramuscular..

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