Journal article
Hormone therapy in postmenopausal women and risk of endometrial hyperplasia
Sue Furness, Helen Roberts, Jane Marjoribanks, Anne Lethaby, Martha Hickey, Cindy Farquhar
COCHRANE DATABASE OF SYSTEMATIC REVIEWS | WILEY | Published : 2009
Abstract
BACKGROUND: Declining circulating estrogen levels around the time of the menopause can induce unacceptable symptoms that affect the health and well being of women. Hormone therapy (both unopposed estrogen and estrogen/progestogen combinations) is an effective treatment for these symptoms, but is associated with risk of harms. Guidelines recommend that hormone therapy be given at the lowest effective dose and treatment should be reviewed regularly. The aim of this review is to identify the minimum dose(s) of progestogen required to be added to estrogen so that the rate of endometrial hyperplasia is not increased compared to placebo. OBJECTIVES: The objective of this review is to assess which ..
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Funding Acknowledgements
[ "Internal sources", "Dept of Obstetrics and Gynaecology, University of Auckland, New Zealand.", "External sources", "Health Research Council, New Zealand." ]