Journal article
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
EY Tan, M Yan, L Campo, C Han, E Takano, H Turley, I Candiloro, F Pezzella, KC Gatter, EKA Millar, SA O'Toole, CM McNeil, P Crea, D Segara, RL Sutherland, AL Harris, SB Fox
British Journal of Cancer | Published : 2009
Abstract
Basal-like tumours account for 15% of invasive breast carcinomas and are associated with a poorer prognosis and resistance to therapy. We hypothesised that this aggressive phenotype is because of an intrinsically elevated hypoxic response. Microarrayed tumours from 188 patients were stained for hypoxia-inducible factor (HIF)-1α, prolyl hydroxylase (PHD)1, PHD2, PHD3 and factor inhibiting HIF (FIH)-1, and carbonic anhydrase (CA) IX stained in 456 breast tumours. Tumour subtypes were correlated with standard clincopathological parameters as well as hypoxic markers. Out of 456 tumours 62 (14%) tumours were basal-like. These tumours were positively correlated with high tumour grade (P<0.001) and..
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Funding Acknowledgements
This study has been supported by the National Medical Research Council (NMRC), Singapore, the Victorian Breast Cancer Research Consortium, Australia, the Victorian Cancer Biobank, the European Union 6th Framework Euroxy, NHS Biomedical Research Centre Oxford, Cancer Research UK, the National Health and Medical Research Council of Australia (NHMRC), the Cancer Institute NSW, the RT Hall Trust and the Petre Foundation. We would also like to thank Dr Kingsley Micklem for help with the photomicrographs.