Journal article

Respiratory Function During Infancy in Survivors of the INNOVO Trial

Ah-Fong Hoo, Caroline S Beardsmore, Rosemary A Castle, Sarath C Ranganathan, Keith Tomlin, David Field, Diana Elbourne, Janet Stocks

Pediatric Pulmonology | WILEY | Published : 2009

Abstract

RATIONALE: Despite encouraging reports suggesting that inhaled nitric oxide (iNO) appear to improve outcome in hypoxemic term and near term infants by improving oxygenation and reducing need for ECMO, the long-term benefits of iNO remain unclear. This study aimed to compare lung function at approximately 1 year in infants who were and were not randomly allocated to iNO as part of their neonatal management for severe respiratory failure at birth. Furthermore, results were compared to lung function of healthy infants. METHODS: Maximal expiratory flow at functional residual capacity (V'maxFRC) was measured at approximately 1 year of age (corrected for any prematurity) in survivors of the INNOVO..

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Grants

Funding Acknowledgements

Grant sponsor: Medical Research Council; Grant sponsor: Portex Ltd., UCL Institute of Child Health; Grant sponsor: Great Ormond Street Hospital for Children, NHS Trust.We thank the parents and children who participated in the respiratory follow-up study, Ann Truesdale from the INNOVO trial steering committee for all her support and advice, and the Clinical Trial Service Unit for provision of the randomization service, Jenny Westaway, Helen Clarkson, Iris Goetz, and Sooky Lum for their help with data collection and analysis. This manuscript is dedicated to the memory of Rosemary Castle, who made an invaluable contribution to this respiratory follow-up, but tragically died before it could be published.