Journal article
Risk factors for cardiovascular disease do not fully explain differences in carotid intima-media thickness between Indigenous and European Australians without diabetes
L Maple-Brown, A Hodge, J Cunningham, DS Celermajer, K O'Dea
Clinical Endocrinology | WILEY | Published : 2009
Abstract
Objective To investigate whether cardiovascular risk factors can explain the higher carotid intima-media thickness (CIMT) in Indigenous compared with European Australians. Design Cross-sectional study in three subgroups. Patients Non-diabetic urban European (n = 86), urban Indigenous (n = 69), and remote Indigenous (n = 60) Australians aged 25-64 years. Measurements CIMT, age, sex, anthropometry, blood pressure, smoking status, fasting glucose and insulin, haemoglobin (Hb)A1c, homocysteine, C-reactive protein (CRP), lipids, urinary albumin and creatinine. Results CIMT and levels of risk factors, except fasting glucose and total cholesterol, worsened across the three groups. Logn fasting insu..
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Awarded by NHMRC
Funding Acknowledgements
We thank Julie Brimblecombe, Loyla Leysley and other staff of the MSHR Chronic Disease Team; members, Health Services and Councils of Galiwinku; DRUID study participants, study staff, Indigenous Steering Group and partner organizations; Members of the Department of Cardiology, Royal Prince Alfred Hospital, for help in CIMT training and analysis; and Dr Kevin Rowley, Department of Medicine, St Vincent's Hospital Melbourne, for CRP measurement. L.M.-B. had an NHMRC Scholarship 2003-5 and is supported by the Centre of Clinical Research Excellence in Clinical Science in Diabetes, University of Melbourne. A.H. is supported by an NHMRC Fellowship (520316) and J.C. had an NHMRC Career Development Award (no. 283310). The remote project was funded by NHMRC (no. 124319) and vascular studies by Diabetes Australia Research Trust, Pfizer CVL and Eli Lilly Endocrinology Research Grant. The DRUID Study was funded by NHMRC (no. 236207), the Department of Employment and Workplace Relations, the Clive and Vera Ramaciotti Foundation, the Vincent Fairfax Family Foundation, Australia@Risk Partnership in Type 2 Diabetes, and Bayer HealthCare.