Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
Ida LM Candiloro, Alexander Dobrovic
CANCER PREVENTION RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2009
Methylation of the CpG island in the MGMT promoter region is a frequent event in several cancer types including colorectal cancer, lung cancer, lymphoma, and glioblastoma. A correlation between methylation and the T allele of the rs16906252 single nucleotide polymorphism (SNP) in colorectal carcinomas has previously been reported. As aberrant MGMT methylation can be an early event in tumor development, we tested the hypothesis that normal individuals possessing the T allele may be predisposed to somatic methylation at the MGMT promoter. Peripheral blood monononuclear cell DNA from 89 normal, healthy individuals was genotyped at rs1690625 and assessed for the methylation status of the MGMT pr..View full abstract
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Awarded by Department of Defense Breast Cancer Research Program
This study was supported in part by a grant to A. Dobrovic from the Department of Defense Breast Cancer Research Program under award number W81XWH-05-1-0500. Views and opinions of and endorsements by the author(s) do not reflect those of the U. S. Army or the Department of Defense. Funding was also obtained from the National Breast Cancer Foundation of Australia and the Cancer Council of Victoria. I. Candiloro is supported by a Fay Marles Scholarship from the University of Melbourne.