Journal article
The spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease
M Loeve, PTW Van Hal, P Robinson, PA De Jong, MH Lequin, WC Hop, TJ Williams, GD Nossent, HA Tiddens
Thorax | Published : 2009
Abstract
Rationale: In cystic fibrosis (CF), lung disease is the predominant cause of morbidity and mortality. Little is known about the spectrum of structural abnormalities on. CT scans from patients with CF with severe advanced lung disease (SALD). No specific CT scoring system for SALD is available. Objectives: To design a quantitative CT scoring system for SALD, to determine the spectrum of structural abnormalities in patients with SALD and to correlate the SALD system with an existing scoring system for mild CF lung disease and pulmonary function tests (PFTs). Methods: 57 patients with CF contributed one CT made during screening for lung transplantation. For the SALD system, lung tissue was divi..
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Funding Acknowledgements
Funding: This study was supported by grants from the Sophia CF research fund; the CF Trust of the Royal Children's Hospital, Melbourne, Australia; the Dutch Cystic Fibrosis Foundation (NCFS); and the Italian CF Fund (IERFC). None of the sponsors was involved in the study design, data collection, analysis, interpretation of data, writing of the report, or in the decision to submit the paper for publication.