Review Paper: A Review of the Cellular Response on Electrospun Nanofibers for Tissue Engineering
DR Nisbet, JS Forsythe, W Shen, DI Finkelstein, MK Horne
JOURNAL OF BIOMATERIALS APPLICATIONS | SAGE PUBLICATIONS LTD | Published : 2009
Electrospinning has been employed extensively in tissue engineering to generate nanofibrous scaffolds from either natural or synthetic biodegradable polymers to simulate the cellular microenvironment. Electrospinning rapidly produces fibers of the nanolength scale and the process offers many opportunities to tailor the physical, chemical, and biological properties of a material for specific applications and cellular environments. There is growing evidence that nanofibers amplify certain biological responses such as contact guidance and differentiation, however this has not been fully exploited in tissue engineering. This review addresses the cellular interactions with electrospun scaffolds, ..View full abstract
Awarded by ARC Discovery-Project
We are grateful to the Australian postgraduate award and the Cooperative Research Centre (CRC) for Polymers for funding David Nisbet. We also acknowledge the ARC Discovery-Project Grant DP0663573 for funding and Amanda Melville with assistance with certain sections of this review.