Journal article

A community-based study of the incidence of trimethoprim-sulfamethoxazole - Preventable infections in Malawian adults living with HIV

JJG van Oosterhout, MK Laufer, SM Graham, F Thumba, MA Perez, N Chimbiya, L Wilson, M Chagomerana, ME Molyneux, EE Zijlstra, TE Taylor, CV Plowe

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2005

Abstract

The benefits of trimethoprim-sulfamethoxazole (TS) prophylaxis reported for persons living with HIV in Cote d'Ivoire are difficult to extrapolate to sub-Saharan African countries where bacterial resistance to TS is higher and cross-resistance between TS and sulfadoxine-pyrimethamine (SP) may impair SP efficacy for malaria treatment. We conducted a community-based cohort study to measure the incidence of potentially TS-preventable illnesses in Blantyre, Malawi. We found a high incidence of malaria, invasive bacterial infections, and probable bacterial pneumonias but low rates of Pneumocystis jiroveci pneumonia, isosporiasis, and Toxoplasma encephalitis. Most bacterial isolates were resistant ..

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