The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
Timothy R Hercus, Daniel Thomas, Mark A Guthridge, Paul G Ekert, Jack King-Scott, Michael W Parker, Angel F Lopez
BLOOD | AMER SOC HEMATOLOGY | Published : 2009
Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha-chain, the first member of the GM-CSF/interleukin (IL)-3/IL-5 family of hemopoietic cytokine receptors to be molecularly characterized. The intervening 2 decades have uncovered a plethora of biologic functions transduced by the GM-CSF receptor (pleiotropy) and revealed distinct signaling networks that couple the receptor to biologic outcomes. Unlike other hemopoietin receptors, the GM-CSF receptor has a significant nonredundant role in myeloid hematologic malignancies, macrophage-mediated acute and chronic inflammation, pulmonary homeostasis, and allergic disease. Th..View full abstract
Awarded by National Institutes of Health
This work was supported by the National Health and Medical Research Council of Australia ( Canberra, Australia), National Institutes of Health ( NIH, Bethesda, MD; RO1-AI50744-02), the Australian Cancer Research Foundation ( Sydney, Australia), the Cancer Council South Australia ( Adelaide, Australia), the Leukemia Research Fund ( Melbourne, Australia), the Children's Cancer Center Foundation ( Melbourne, Australia), Australian Research Council Federation Fellowship ( Canberra, Australia), and Sylvia and Charles Viertel Senior Medical Fellowship ( Melbourne, Australia).