Journal article

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Timothy R Hercus, Daniel Thomas, Mark A Guthridge, Paul G Ekert, Jack King-Scott, Michael W Parker, Angel F Lopez

BLOOD | AMER SOC HEMATOLOGY | Published : 2009

Abstract

Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha-chain, the first member of the GM-CSF/interleukin (IL)-3/IL-5 family of hemopoietic cytokine receptors to be molecularly characterized. The intervening 2 decades have uncovered a plethora of biologic functions transduced by the GM-CSF receptor (pleiotropy) and revealed distinct signaling networks that couple the receptor to biologic outcomes. Unlike other hemopoietin receptors, the GM-CSF receptor has a significant nonredundant role in myeloid hematologic malignancies, macrophage-mediated acute and chronic inflammation, pulmonary homeostasis, and allergic disease. Th..

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Grants

Awarded by National Institutes of Health


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia ( Canberra, Australia), National Institutes of Health ( NIH, Bethesda, MD; RO1-AI50744-02), the Australian Cancer Research Foundation ( Sydney, Australia), the Cancer Council South Australia ( Adelaide, Australia), the Leukemia Research Fund ( Melbourne, Australia), the Children's Cancer Center Foundation ( Melbourne, Australia), Australian Research Council Federation Fellowship ( Canberra, Australia), and Sylvia and Charles Viertel Senior Medical Fellowship ( Melbourne, Australia).