Journal article

Refractory subacute cutaneous lupus erythematosus successfully treated with rituximab

Violet Kieu, Timothy O'Brien, Lee-Mei Yap, Christopher Baker, Peter Foley, Graham Mason, H Miles Prince, Christopher McCormack

AUSTRALASIAN JOURNAL OF DERMATOLOGY | WILEY-BLACKWELL PUBLISHING, INC | Published : 2009

Abstract

A 48-year-old woman presented with pruritic, scaly, annular plaques over her upper back and chest that were clinically, serologically and histologically characteristic of subacute cutaneous lupus erythematosus (SCLE). She failed to respond to conventional treatment, which included high-dose hydroxychloroquine, methotrexate, prednisolone, chloroquine, acitretin, thalidomide, dapsone and azathioprine. Subsequently treated with intravenous rituximab 375 mg/m(2) weekly for 4 weeks, she remained on adjuvant oral hydrochloroquine 600 mg daily and topical clobetasol propionate 0.05% ointment as required. Clearing of annular plaques was noted 8 weeks after the initial course of rituximab. By 12 week..

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