Journal article

Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke

Tobias Neumann-Haefelin, Silke Hoelig, Joachim Berkefeld, Jens Fiehler, Achim Gass, Marek Humpich, Andreas Kastrup, Thomas Kucinski, Olivera Lecei, David S Liebeskind, Joachim Rother, Charlotte Rosso, Yves Samson, Jeffrey L Saver, Bernhard Yan



BACKGROUND AND PURPOSE: The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis for acute stroke. METHODS: In this retrospective, multicenter analysis, we evaluated data from acute anterior circulation stroke patients (n=449; <6 hours after symptom onset) treated with thrombolysis. All patients had received standard magnetic resonance imaging evaluation before thrombolysis, including a high-quality T2-weighted sequence. For the analysis, LA in the deep white matter was dichotomized into absent or mild versus moderate or severe (corresponding to Fazekas scores of 0 to 1 versus 2 to 3..

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