Journal article
Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke
T Neumann-Haefelin, S Hoelig, J Berkefeld, J Fiehler, A Gass, M Humpich, A Kastrup, T Kucinski, O Lecei, DS Liebeskind, J Rother, C Rosso, Y Samson, JL Saver, B Yan
Stroke | Published : 2006
Abstract
BACKGROUND AND PURPOSE - The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis for acute stroke. METHODS - In this retrospective, multicenter analysis, we evaluated data from acute anterior circulation stroke patients (n=449; <6 hours after symptom onset) treated with thrombolysis. All patients had received standard magnetic resonance imaging evaluation before thrombolysis, including a high-quality T2-weighted sequence. For the analysis, LA in the deep white matter was dichotomized into absent or mild versus moderate or severe (corresponding to Fazekas scores of 0 to 1 versus 2 to..
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