Journal article

HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis

J Stankovich, H Butzkueven, M Marriott, C Chapman, N Tubridy, BD Tait, MD Varney, BV Taylor, SJ Foote, TJ Kilpatrick, JP Rubio

TISSUE ANTIGENS | WILEY | Published : 2009

Abstract

Human leucocyte antigen (HLA)-DRB1*1501 and other class II alleles influence susceptibility to multiple sclerosis (MS), but their contribution if any to the clinical course of MS remains uncertain. Here, we have investigated DRB1 alleles in a large sample of 1230 Australian MS cases, with some enrichment for subjects with primary progressive (PPMS) disease (n = 246) and 1210 healthy controls. Using logistic regression, we found that DRB1*1501 was strongly associated with risk (P = 7 x 10(-45)), as expected, and after adjusting for DRB1*1501, a predisposing effect was also observed for DRB1*03 (P = 5 x 10(-7)). Individuals homozygous for either DRB1*15 or DRB1*03 were considerably more at ris..

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