Relaxin Family Peptides and Receptors in Mammalian Brain Anatomical Insights and Diverse Functional Possibilities
Andrew L Gundlach, Sherie Ma, Qian Sang, Pei-Juan Shen, Loretta Piccenna, Katayoun Sedaghat, Craig M Smith, Ross AD Bathgate, Andrew J Lawrence, Geoffrey W Tregear, John D Wade, David I Finkelstein, Pascal Bonaventure, Changlu Liu, Timothy W Lovenberg, Steve W Sutton, GD BryantGreenwood (ed.), CA Bagnell (ed.), RAD Bathgate (ed.)
RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE | BLACKWELL PUBLISHING | Published : 2009
As a foundation for regulatory and functional studies of central relaxin family peptide receptor systems, we are mapping the distribution of the different receptors in the brain of rat, mouse, and nonhuman primates, attempting to identify the nature of the receptor-positive neurons in key circuits and establish the complementary distribution of the respective ligands in these species. Here we review progress in mapping RXFP1, RXFP2, and RXFP3 (mRNAs and proteins) and their respective ligands and discuss some of the putative functions for these peptides and receptors that are being explored using receptor-selective agonist and antagonist peptides and receptor and peptide gene deletion mouse s..View full abstract
Research from the primary author's laboratory which has been reviewed here was Supported by the National Health and Medical Research Council of Australia, Johnson & Johnson Pharmaceutical Research & Development, LLC (USA), the Howard Florey Biomedical Foundation (USA), and the Brain Foundation (Australia).