Journal article

Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation

Maarten van den Buuse, Lena Wischhof, Ruo Xi Lee, Sally Martin, Tim Karl



Neuregulin 1 (Nrg1) has been widely recognized as a candidate gene for schizophrenia. This study therefore investigated mice heterozygous for a mutation in the transmembrane domain of this trophic factor (Nrg1+/- mice) in a number of behavioural test systems with relevance to schizophrenia, including psychotropic drug-induced locomotor hyperactivity and prepulse inhibition (PPI) of startle. Baseline locomotor activity in the open field or in photocell cages was slightly, but significantly enhanced in Nrg1+/- mice compared to wild-type littermate controls at age 12-16 wk, but not at age 6 months. The ability of amphetamine, phencyclidine (PCP) or MK-801 to induce locomotor hyperactivity was n..

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Awarded by NHMRC

Funding Acknowledgements

M. van den Buuse is a Senior Research Fellow of the National Health and Medical Research Council of Australia (NHMRC). These studies were supported by the Percy Baxter Charitable Trust, Operational Infrastructure Support (OIS) from the Victorian State Government, the Schizophrenia Research Institute (utilizing infrastructure funding from NSW Health), and the Sylvia and Charles Viertel Charitable Foundation. T. Karl was supported by a Bill Ritchie Post-doctoral Research Fellowship and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award and a project grant from the NHMRC (493301). The critical comments on the manuscript by Jerry Tanda are gratefully acknowledged. Dr Richard Harvey of the Victor Chang Institute, Sydney, is acknowledged for providing the original breeding pairs which were used to establish the breeding colony at the Garvan Institute, Sydney.