Journal article
IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo - effects of anti-inflammatory pharmacotherapy
O Prause, A Bossios, E Silverpil, S Ivanov, S Bozinovski, R Vlahos, M Sjöstrand, GP Anderson, A Lindén
Pulmonary Pharmacology and Therapeutics | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2009
Abstract
Interleukin (IL)-17 may play a critical role for the innate immune response in mammals. However, little is known about its production in T lymphocytes in comparison with other cells, in lung tissue and in the bronchoalveolar space in vivo. Even less is known about the effects of anti-inflammatory pharmacotherapy on this IL-17 production. In this study on mice we show that one single, intranasal exposure to endotoxin from Escherichia coli increases extracellular IL-17 protein in bronchoalveolar (BAL) samples during 3 days, and is accompanied by a local increase in neutrophils and other inflammatory cells. This endotoxin exposure also elevates IL-17 mRNA in lung tissue samples. Moreover, after..
View full abstractGrants
Awarded by Göteborgs Universitet
Funding Acknowledgements
Authors O.P. and A.B. contributed equally to this work. The study was financially supported by the University of Gothenburg as well as the Heart-Lung Foundation and the Science Council (K2005-74X-09048-16A and K2008-57X-09048-19-3) in Sweden. A.B. received financial support from a grant from "EMPIRIKION foundation", Athens, Greece. The authors thank Jessica Jones, B.Sci., for excellent technical assistance. No support, either direct or indirect, was obtained from the tobacco industry.