Journal article

Stability of methoxyflurane loaded Penthrox Inhaler

DP Crankshaw

Journal of Pharmacy Practice and Research | Published : 2009


Background: Methoxyflurane (MEOF), a non-narcotic inhalational anaesthetic, administered with the Penthrox Inhaler is effective in managing acute pain. Despite widespread use by ambulance services, its use in emergency departments and hospital wards has been limited. MEOF storage to minimise evaporation would facilitate pre-filling inhalers for multiple treatment use. Aim: To ascertain if Penthrox Inhalers loaded with MEOF can be stored for extended periods without appreciable loss of MEOF. Method: 18 Penthrox Inhalers were loaded with MEOF 3 mL and weighed over 87 hours. 6 inhalers were left in the open, 6 inhalers stored in the packing boxes and 6 inhalers sealed in low-density polyethylen..

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