Journal article

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

Duncan J Campbell, Juerg Nussberger, Michael Stowasser, AH Jan Danser, Alberto Morganti, Erik Frandsen, Joel Menard



BACKGROUND: Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the plasma renin activity (PRA) assay and the renin immunoassay. The clinical application of renin inhibitor therapy has thrown into focus the differences in information provided by activity assays and immunoassays for renin and prorenin measurement and has drawn attention to the need for precautions to ensure their accurate measurement. CONTENT: Renin activity assays and immunoassays provide related but different information. Whereas activity assays measure only active renin, immunoassays measure both active and inhibited renin. Pa..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

D.I. Campbell, Senior Research Fellowship from the National Health and Medical Research Council of Australia (Grant ID 395508), grant support from the National Heart Foundation of Australia, and research contracts with Solvay pharmaceutical Company and Novartis Pharmaceuticals; J. Nussberger, Novartis Pharmaceuticals; A.H.J. Danser, Novartis Pharmaceuticals. Expert Testimony: None declared.