Journal article
Long-Chain ω-3 Fatty Acids for Indicated Prevention of Psychotic Disorders
G Paul Amminger, Miriam R Schäfer, Konstantinos Papageorgiou, Claudia M Klier, Sue M Cotton, Susan M Harrigan, Andrew Mackinnon, Patrick D McGorry, Gregor E Berger
Archives of General Psychiatry | American Medical Association (AMA) | Published : 2010
Abstract
CONTEXT: The use of antipsychotic medication for the prevention of psychotic disorders is controversial. Long-chain omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) may be beneficial in a range of psychiatric conditions, including schizophrenia. Given that omega-3 PUFAs are generally beneficial to health and without clinically relevant adverse effects, their preventive use in psychosis merits investigation. OBJECTIVE: To determine whether omega-3 PUFAs reduce the rate of progression to first-episode psychotic disorder in adolescents and young adults aged 13 to 25 years with subthreshold psychosis. DESIGN: Randomized, double-blind, placebo-controlled trial conducted between 2004 and 2007..
View full abstract