No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression
Phillip Chipman, Anthony F Jorm, Xiao-Yan Tan, Simon Easteal
PSYCHIATRIC GENETICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
BACKGROUND: There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders. METHODS: In our study we investigated associations between this polymorphism and symptoms of anxiety and depression in a population sample of 6445 Caucasians in the age groups 20-24, 40-44, and 60-64 years. We also looked for interactions between the polymorphism and environmental stressors of childhood adversity or recent stressful life events on anxiety and depression. RESULTS: There were no significant associations between the polymorphism and anxiety, depression or associated personality t..View full abstract
The authors wish to thank Helen Christensen, Bryan Rodgers, Trish Jacomb, Karen Mather, Zoe Prichard, Holly Mack, and the PATH interviewers for their contribution to the data from the PATH project. Funding for the PATH project came from National Health and Medical Research Council Unit and Program Grants.