Journal article

No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression

Phillip Chipman, Anthony F Jorm, Xiao-Yan Tan, Simon Easteal

PSYCHIATRIC GENETICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010

Abstract

BACKGROUND: There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders. METHODS: In our study we investigated associations between this polymorphism and symptoms of anxiety and depression in a population sample of 6445 Caucasians in the age groups 20-24, 40-44, and 60-64 years. We also looked for interactions between the polymorphism and environmental stressors of childhood adversity or recent stressful life events on anxiety and depression. RESULTS: There were no significant associations between the polymorphism and anxiety, depression or associated personality t..

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