Analysis of the platypus genome suggests a transposon origin for mammalian imprinting
Andrew J Pask, Anthony T Papenfuss, Eleanor I Ager, Kaighin A Mccoll, Terence P Speed, Marilyn B Renfree
GENOME BIOLOGY | BIOMED CENTRAL LTD | Published : 2009
BACKGROUND: Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression. Many hypotheses have been advanced to explain why genomic imprinting evolved in mammals, but few have examined how it arose. The host defence hypothesis suggests that imprinting evolved from existing mechanisms within the cell that act to silence foreign DNA elements that insert into the genome. However, the changes to the mammalian genome that accompanied the evolution of imprinting have been hard to define due to the absence of large scale genomic resources between all extant classes. The recent release of the platypus genome has provided the first opportunity to perform comparisons betw..View full abstract
AJP is supported by a National Health and Medical Research Council RD Wright Fellowship, and MBR is supported by an Australian Research Council Federation Fellowship. ATP, TPS and KMcC are supported by the National Health and Medical Research Council of Australia.