The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy.

EL Fletcher; LE Downie; K Hatzopoulos; KA Vessey; MM Ward; CL Chow; MJ Pianta; AJ Vingrys; M Kalloniatis; JL Wilkinson-Berka

Journal article

The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy.

EL Fletcher, LE Downie, K Hatzopoulos, KA Vessey, MM Ward, CL Chow, MJ Pianta, AJ Vingrys, M Kalloniatis, JL Wilkinson-Berka

Documenta Ophthalmologica Advances in Ophthalmology | Published : 2010

DOI: 10.1007/s10633-009-9193-6

Abstract

Retinopathy of prematurity is a devastating vascular disease of premature infants. A number of studies indicate that retinal function is affected in this disease. Using the rat model of oxygen-induced retinopathy, it is possible to explore more fully the complex relationship between neuronal, glial and vascular pathology in this condition. This review examines the structural and functional changes that occur in the rat retina following oxygen-induced retinopathy. We highlight that vascular pathology in rats is characterized by aberrant growth of blood vessels into the vitreous at the expense of blood vessel growth into the body of the retina. Moreover, amino acid neurochemistry, a tool for e..

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University of Melbourne Researchers

Erica Fletcher Author

Laura Downie Author

Kate Hatzopoulos Author

Kirstan Vessey Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC grant #566815 to E. L. F. and #350224 to A. J.V., and #299974 to J. W.-B. & E. L. F.) J. W.-B. is an NHMRC Senior Research Fellow B.