Journal article
Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease
Christel Cazalet, Laura Gomez-Valero, Christophe Rusniok, Mariella Lomma, Delphine Dervins-Ravault, Hayley J Newton, Fiona M Sansom, Sophie Jarraud, Nora Zidane, Laurence Ma, Christiane Bouchier, Jerome Etienne, Elizabeth L Hartland, Carmen Buchrieser
PLOS GENETICS | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Legionella pneumophila and L. longbeachae are two species of a large genus of bacteria that are ubiquitous in nature. L. pneumophila is mainly found in natural and artificial water circuits while L. longbeachae is mainly present in soil. Under the appropriate conditions both species are human pathogens, capable of causing a severe form of pneumonia termed Legionnaires' disease. Here we report the sequencing and analysis of four L. longbeachae genomes, one complete genome sequence of L. longbeachae strain NSW150 serogroup (Sg) 1, and three draft genome sequences another belonging to Sg1 and two to Sg2. The genome organization and gene content of the four L. longbeachae genomes are highly cons..
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Awarded by Network of Excellence "Europathogenomics''
Awarded by European Commission
Funding Acknowledgements
This work received financial support from the Institut Pasteur, the Centre National de la Recherche (CNRS), the Network of Excellence "Europathogenomics'' LSHB-CT-2005-512061, and the Australian National Health and Medical Research Council (NHMRC). ML is holder of a Marie Curie fellowship financed by the European Commission (INTRAPATH project MEST-CT-2005-020715) coordinated by Institut Pasteur and LG-V is holder of a Roux postdoctoral research Fellowship financed by the Institut Pasteur. ELH holds an Australian Research Council Future Fellowship. HJN and FMS hold NHMRC Biomedical Training fellowships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.