On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues
Lihai Zhang, Bruce S Gardiner, David W Smith, Peter Pivonka, Alan J Grodzinsky
Journal of Theoretical Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2010
Here a reactive-diffusion transport model is used to demonstrate two previously undescribed functional roles for diffusible binding partners in the transport of molecules into tissues. The uptake of the insulin-like growth (IGF) and its binding partner the IGF binding protein (IGFBP3) into cartilage is used a specific tissue example to demonstrate a general principal. First, we show that reversible binding between free protein (IGF) and its diffusible binding partner (free IGFBPs) increases the rate of protein uptake into the tissue. Second, selective degradation of the binding partner can increase the transient and steady state free protein in tissues, well above the concentration at the so..View full abstract
Awarded by Australian Research Council
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
The authors wish to thank The Australian Research Council (DP50192), The University of Melbourne, and NIH Grant AR33236 for their support.