Journal article

Dissecting the apicomplexan rhoptry neck proteins

Nicholas I Proellocks, Ross L Coppel, Karena L Waller

TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2010

Abstract

Apicomplexan parasites possess specialized secretory organelles (rhoptries and micronemes) that release their contents during host cell invasion. Although the rhoptries were once thought to be merely a bulbous 'protein reservoir' connected to an anterior neck region, the localization of a protein specifically to the neck suggested that this region was more than just a duct. Recent studies have shown that the rhoptry neck sub-compartment possesses a distinct protein repertoire. Some of these proteins share common features, including conservation across the phylum and involvement in tight-junction formation. A sub-group of rhoptry neck proteins, the RONs, their association with the microneme p..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

This work was supported by the Malaria Programme Grant from the National Health and Medical Research Council (NHMRC) of Australia NIP was supported by an Australian Postgraduate Award and KLW was supported by an NHMRC Howard Florey Centenary Research Fellowship