Journal article
Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease
MT Fodero-Tavoletti, VL Villemagne, BM Paterson, AR White, QX Li, J Camakaris, G O'keefe, R Cappai, KJ Barnham, PS Donnelly
Journal of Alzheimer S Disease | IOS PRESS | Published : 2010
Abstract
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden. © 2010 - IOS Press and the authors.
Grants
Funding Acknowledgements
We thank: Angela Rigopoulos and Diana Cao for assistance with animal imaging studies, Mark Greenough for assistance with <SUP>64</SUP>Cu handling, and Dr. HenriTochon Danguy and Dr. Uwe Ackermann for provision of radiochemistry facilities. This work was supported by the Australian Research Council, the National Health and Medical Research Council and the Australian Institute of Nuclear Science and Engineering.