Journal article

Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection

Matthew DH Lay, Lei Zhang, Ruy M Ribeiro, Scott N Mueller, Gabrielle T Belz, Miles P Davenport



Ag presentation within the regional lymph node is crucial for the initiation of CD8+ T cell responses following viral infection. The magnitude and quality of the CD8+ T cell response are regulated by the interplay between the size of the APC population and duration of Ag presentation. To understand how these parameters are finely regulated during an immune response, we have investigated the dynamics of Ag presentation in influenza A virus and HSV-1 infection. In both infections, APC production was calculated to occur over the first few days of infection, after which there was slow exponential decay over a period of up to 2 wk. This production rate is most likely determined by the Ag availabi..

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Funding Acknowledgements

This work was supported by the James S. McDonnell Foundation 21st Century Research Award/Studying Complex Systems. the National Health and Medical Research Council (Australia, to M.P.D. and G.T.B.). Howard Hughes Medical Institute (to G.T.B.), Wellcome Trust (United Kingdom, to G.T.B.), and the U.S. Department of Energy through the Los Alamos National Laboratory/Laboratory Directed Research and Development Program (to R.M.R.). M.P.D. is supported by a Sylvia and Charles Viertel Charitable Foundation senior medical research fellowship. and G.T.B. is supported by a Wellcome Trust senior overseas fellowship.