Journal article

PROTEOLYTIC ACTIVITY DURING CORTICAL DEVELOPMENT IS DISTINCT FROM THAT INVOLVED IN HYPOXIC ISCHEMIC INJURY

HS Ranasinghe, CE Williams, LJ Christophidis, MD Mitchell, M Fraser, A Scheepens

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in brain development and the etiology of adult cerebral injuries. In this study, we determined the MMP-2 and 9 responses following hypoxic ischemia (HI) injury in the developing brain. First, we characterized the developmental changes of MMP activity in the rat brain from embryonic day 18 (E18) to postnatal day 120 (P120). MMP-2 activity was high from E18 to P3 and decreased with age (P< or =0.001), while MMP-9 activity was not detectable. MMP-2 immunoreactivity was closely associated with differentiating cortical plate and subplate neurons. Next, we characterized the proteolytic changes after unilateral ..

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University of Melbourne Researchers