A Role for Omega-3 Polyunsaturated Fatty Acid Supplements in Diabetic Neuropathy
Peter Yee, Anne E Weymouth, Erica L Fletcher, Algis J Vingrys
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2010
PURPOSE: Diabetes results in an insulin-related disorder of lipid metabolism that reduces production of long-chain polyunsaturated fatty acids (PUFAs; e.g., docosahexanoic acid, DHA). This study considers the role that this lipid change has on retinal function. METHODS: From conception, rats (n = 56) were fed diets either balanced (n = 32) in PUFAs or deficient in omega-3 (n = 24). Half were assigned to control (n = 28) or streptozotocin (STZ: n = 28) treatment at 7 weeks of age. Key metabolic indices were assayed at 19 weeks, and retinal function was determined by electroretinogram (ERG) at 20 weeks. Retinal anatomy and lipid assays of 20-week-old animals were used to identify structural ch..View full abstract
Awarded by National Health and Medical Research Council
Supported by National Health and Medical Research Council Grants 350434 (ELF) and 350224 (AJV) and the Diabetes Australia Research Trust (ELF).