Conference Proceedings

Corrected statistical distance and probability constrained optimization in reconstruction of phylogenetic trees

DA Thomas, JF Weng, I Mareels

2nd International Conference on Bioinformatics and Computational Biology 2010, BICoB 2010 | Published : 2010


The phylogenetic tree problem asks for a tree on a given set of organisms (represented by nucleotide sequences), showing the evolutionary relationships among these organisms. Because uncertain characters and gaps exist in the input sequences and because the inferred internal nodes and edge lengths in the tree are not unique, a probability representation model for phyloge-netic trees has been proposed by the authors. In this model a probability distribution of nucleotide states for each node on each site is inferred, and edge lengths are measured based on the statistical distance between the probability distributions of nucleotides, which is equivalent to the Hamming distance between nucleoti..

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