Evaluation of immunological responses to a glycoprotein G deficient candidate vaccine strain of infectious laryngotracheitis virus
Joanne M Devlin, Abel Viejo-Borbolla, Glenn F Browning, Amir H Noormohammadi, James R Gilkerson, Antonio Alcami, Carol A Hartley
VACCINE | ELSEVIER SCI LTD | Published : 2010
Infectious laryngotracheitis virus (ILTV), an alphaherpesvirus, causes severe respiratory disease in poultry. Glycoprotein G (gG) is a virulence factor in ILTV. Recent studies have shown that gG-deficient ILTV is an effective attenuated vaccine however the function of ILTV gG is unknown. This study examined the function and in vivo relevance of ILTV gG. The results showed that ILTV gG binds to chemokines with high affinity and inhibits leukocyte chemotaxis. Specific-pathogen-free (SPF) chickens infected with gG-deficient virus had altered tracheal leukocyte populations and lower serum antibody levels compared with those infected with the parent virus. The findings suggest that the absence of..View full abstract
This work was supported by funding from the Australian Research Council (ARC). Joanne Devlin is supported by an ARC postdoctoral fellowship. Abel Viejo-Borbolla is supported by a postdoctoral contract program from the Instituto de Salud Carlos III (Spanish Ministry of Health).