A Comprehensive Neuropsychiatric Study of Elderly Twins: The Older Australian Twins Study
Perminder S Sachdev, Andrea Lammel, Julian N Trollor, Teresa Lee, Margaret J Wright, David Ames, Wei Wen, Nicholas G Martin, Henry Brodaty, Peter R Schofield
TWIN RESEARCH AND HUMAN GENETICS | CAMBRIDGE UNIV PRESS | Published : 2009
The Older Australian Twins Study (OATS) was recently initiated to investigate genetic and environmental factors and their associations and interactions in healthy brain ageing and ageing-related neurocognitive disorders. The study extends the classic MZ-DZ design to include one or two equivalently aged siblings for each twin pair and utilizes the rich resources of the Australian Twin Registry. The study has a number of distinguishing features including comprehensive psychiatric, neuropsychological, cardiovascular, metabolic, and neuroimaging assessments, a longitudinal design and links with a brain donor program. The study measures many behavioral and environmental factors, but in particular..View full abstract
Awarded by NHMRC/ARC
We thank the participants of the Older Australian Twins Study and the staff of the Australian Twin Registry. We also thank the SEALS Laboratories of the South Eastern Sydney & Illawarra Area Health Service for blood tests, Symbion Imaging for MRI scans, and Symbion Pathology for blood collection. This study is supported by an NHMRC/ARC Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID No. 401126). Angela Russell assisted with the preparation of the manuscript.