Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

Grants

Funding Acknowledgements

We thank Nick Vandegraaff for testing sucrose in the IN assay and Susanne Feil and Mike Gorman for support and advice. We also thank the BioCARS and GM/CA staff for their help at the Advanced Photon Source. This work was supported by the Australian Research Council Linkage project (LP0775192) and the Australian Synchrotron Research Program, which was funded by the Commonwealth of Australia under the Major National Research Facilities Program. Use of the Advanced Photon Source was supported by the U.S. DOE, Basic Energy Sciences and Office of Energy Research. M. W. P. is an ARC Federation Fellow and National Health and Medical Research Council Honorary Fellow.