Erythropoietin Is Neuroprotective in a Preterm Ovine Model of Endotoxin-Induced Brain Injury
Sandra Rees, Nadia Hale, Robert De Matteo, Lisa Cardamone, Mary Tolcos, Michelle Loeliger, Anna Mackintosh, Amy Shields, Megan Probyn, Deanne Greenwood, Richard Harding
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
Intrauterine infection and inflammation have been linked to preterm birth and brain damage. We hypothesized that recombinant human erythropoietin (rhEPO) would ameliorate brain damage in anovine model of fetal inflammation. At 107 +/- 1 day of gestational age (DGA), chronically catheterized fetal sheep received on 3 consecutive days 1) an intravenous bolus dose of lipopolysaccharide ([LPS] approximately 0.9 microg/kg; n = 8); 2) an intravenous bolus dose of LPS, followed at 1 hour by 5,000 IU/kg of rhEPO (LPS + rhEPO, n = 8); or 3) rhEPO (n = 5). Untreated fetuses (n = 8) served as controls. Fetal physiological parameters were monitored, and fetal brains and optic nerves were histologically ..View full abstract
This study was supported by the National Health and Medical Research Council Australia.