The Anti-Inflammatory Agent N-Acetyl Cysteine Exacerbates Endotoxin-Induced Hypoxemia and Hypotension and Induces Polycythemia in the Ovine Fetus
Megan E Probyn, Megan L Cock, Jhodie R Duncan, Mary Tolcos, Nadia Hale, Amy Shields, Sandra M Rees, Richard Harding
NEONATOLOGY | KARGER | Published : 2010
BACKGROUND: Lipopolysaccharide (LPS) delivered acutely to the ovine fetus induces cerebral white matter injury and brain inflammation. N-acetyl cysteine (NAC) is potentially neuroprotective as it blocks the production of inflammatory cytokines and increases glutathione levels; however, it is unknown whether NAC affects the physiological status of the fetus already exposed to an inflammatory environment. OBJECTIVES: Our objective was to determine whether NAC influences the physiological effects of LPS exposure in the ovine fetus. METHODS: Catheterized fetal sheep underwent one of four treatments (saline, n = 6; LPS, n = 6; LPS + NAC, n = 6; NAC, n = 3) on 5 consecutive days from 95 days of ge..View full abstract
The authors are grateful to Alex Satragno and Sally Gregg for their assistance. Funding was provided by the National Health and Medical Research Council of Australia.