The Central Retinal Vein Bypass Study: A Trial of Laser-induced Chorioretinal Venous Anastomosis for Central Retinal Vein Occlusion

Abstract

Purpose: To evaluate the effectiveness of a laser-induced chorioretinal venous anastomosis (L-CRA) as a treatment for nonischemic central retinal vein occlusion (CRVO). Design: Prospective, randomized, controlled, multicenter clinical trial. Participants: A total of 113 consecutive patients with a nonischemic CRVO of >3 months' duration and visual acuity of ≤20/50. Methods: Patients were randomized to L-CRA (58 patients) or conventional care (55 patients). They underwent standardized retinal photography, fluorescein angiography, and ophthalmic examinations, together with standardized assessments of best-corrected visual acuity, performed by masked visual acuity assessors using Early Treatmen..